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Goat Anti-LRRK2 / PARK8 (near C Terminus) Antibody (EB06550)
| Code | Name | Applications | Availability | Size | Tested species | Price | Grade | |
|---|---|---|---|---|---|---|---|---|
| EB06550 | Goat Anti-LRRK2 / PARK8 (near C Terminus) Antibody | Pep-ELISA, WB, IHC, ICC, IEM |  |
100µg specific antibody in 200µl | Human | $315.00 |  |
|
Ordering Information forOrder direct from Everest
$95.00: Overnight shipping to United States of America
Sent via overnight courier arrives approximately next day to mainland USA. Please note that your order will be shipped by our US partner Abcore LLC. Order offline99% of products are held in stock for immediate shipment, see individual product pages for availability. Please order through the US Dollar shopping cart (links on each product page) or we accept orders by email ([email protected])
In stock orders received by 11 am PST on Monday through Friday are shipped the same day. Orders are shipped by our parent company Vector Laboratories, 6737 Mowry Avenue, Newark CA 94560, USA. OR
Order from our local distributorARP American Research Products, IncARP American Research Products, Inc |
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Target Protein
Principal Names: LRRK2, PARK8, ROCO2, FLJ45829, DKFZp434H2111, leucine-rich repeat kinase 2, dardarin, Parkinson disease (autosomal dominant) 8Official Symbol: LRRK2
Accession Number(s): NP_940980.3
Human GeneID(s): 120892
Immunogen
Peptide with sequence CELAEKMRRTSV, from the internal region (near the C Terminus) of the protein sequence according to NP_940980.3.
Please note the peptide is available for sale.
Purification and Storage
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Aliquot and store at -20°C. Minimize freezing and thawing.
Applications Tested
Peptide ELISA: antibody detection limit dilution 1:64000.Western blot: This product has been successfully used in Western blot for human brain as described in the following paper: Sharma et al, Neuropathol Appl Neurobiol. 2011 Jun 23, PMID 21696411. Recommended concentration: 0.3-1µg/ml.
IHC: In paraffin embedded Human Brain (Hippocampus) shows staining of neuronal cytoplasm. Recommended concentration: 1-2µg/ml. Paraffin embedded Human Brain (Cortex). Recommended concentration: 2µg/ml. This product has been successfully used in immunohistochemistry on human brain: Alegre-Abarrategui J et al., Neuropathol Appl Neurobiol. 2007 Oct 26; PMID: 17971075.
Immunoelectron microscopy: This antibody has been successfully used in IEM as described in the following paper: Alegre-Abarrategui et al, Hum Mol Genet. 2009 Nov 1;18(21):4022-34, PMID: 19640926.
ICC: This antibody has also been successfully used in ICC for human neurons as described in: Sharma et al, Neuropathol Appl Neurobiol. 2011 Jun 23, PMID 21696411.
Species Reactivity
Tested: HumanExpected from sequence similarity: Human, Cow
Specific References
This antibody has been successfully used in the following paper:
Alegre-Abarrategui J, Ansorge O, Esiri M, Wade-Martins R.
LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.
Neuropathol Appl Neurobiol. 2007 Oct 26.
PMID: 17971075
This antibody has been successfully used in the following paper:
Sharma S, Bandopadhyay R, Lashley T, Renton AE, Kingsbury AE, Kumaran R, Kallis C, Vilariño-Güell C, O'Sullivan SS, Lees AJ, Revesz T, Wood NW, Holton JL.
LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: A morphological and quantitative study.
Neuropathol Appl Neurobiol. 2011 Jun 23.
PMID: 21696411
This antibody has been successfully used in the following paper:
Alegre-Abarrategui J, Christian H, Lufino MM, Mutihac R, Venda LL, Ansorge O, Wade-Martins R.
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.
Hum Mol Genet. 2009 Nov 1;18(21):4022-34.
PMID: 19640926